| http://purl.uniprot.org/citations/37468628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37468628 | http://www.w3.org/2000/01/rdf-schema#comment | "Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation1-4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacetylates histones H3 and H4 at multiple sites across transcribed regions5-7. Here we solved the cryo-electron microscopy structures of Saccharomyces cerevisiae Rpd3S in its free and H3K36me3 nucleosome-bound states. We demonstrated a unique architecture of Rpd3S, in which two copies of Eaf3-Rco1 heterodimers are asymmetrically assembled with Rpd3 and Sin3 to form a catalytic core complex. Multivalent recognition of two H3K36me3 marks, nucleosomal DNA and linker DNAs by Eaf3, Sin3 and Rco1 positions the catalytic centre of Rpd3 next to the histone H4 N-terminal tail for deacetylation. In an alternative catalytic mode, combinatorial readout of unmethylated histone H3 lysine 4 and H3K36me3 by Rco1 and Eaf3 directs histone H3-specific deacetylation except for the registered histone H3 acetylated lysine 9. Collectively, our work illustrates dynamic and diverse modes of multivalent nucleosomal engagement and methylation-guided deacetylation by Rpd3S, highlighting the exquisite complexity of epigenetic regulation with delicately designed multi-subunit enzymatic machineries in transcription and beyond."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-023-06349-1"xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Ou Y."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Guan H."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Ruan C."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/author | "Peng B."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/pages | "669-675"xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/title | "Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S."xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://purl.uniprot.org/core/volume | "620"xsd:string |
| http://purl.uniprot.org/citations/37468628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37468628 |
| http://purl.uniprot.org/citations/37468628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37468628 |
| http://purl.uniprot.org/uniprot/#_P62799-mappedCitation-37468628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37468628 |
| http://purl.uniprot.org/uniprot/#_Q04779-mappedCitation-37468628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37468628 |
| http://purl.uniprot.org/uniprot/#_P02281-mappedCitation-37468628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37468628 |
| http://purl.uniprot.org/uniprot/#_P22579-mappedCitation-37468628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37468628 |