| http://purl.uniprot.org/citations/37471227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37471227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37471227 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 peptides, in the context of the model allotype HLA-DR1, does not correlate with their binding affinity to the HLA heterodimer. Analyzing six epitopes, some with very low binding affinity, we solve X-ray crystallographic structures of each bound to HLA-DR1. Further structural definitions reveal the precise molecular impact of viral variant mutations on epitope presentation. Omicron escaped ancestral SARS-CoV-2 immunity to two epitopes through two distinct mechanisms: (1) mutations to TCR-facing epitope positions and (2) a mechanism whereby a single amino acid substitution caused a register shift within the HLA binding groove, completely altering the peptide-HLA structure. This HLA-II-specific paradigm of immune escape highlights how CD4+ T cell memory is finely poised at the level of peptide-HLA-II presentation."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112827"xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112827"xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Rizkallah P."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Rizkallah P."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Godkin A."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Godkin A."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Gallimore A.M."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Gallimore A.M."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Greenshields-Watson A."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Greenshields-Watson A."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Long H.M."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Long H.M."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "MacLachlan B.J."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "MacLachlan B.J."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Mason G.H."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Mason G.H."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Haigh T.A."xsd:string |
| http://purl.uniprot.org/citations/37471227 | http://purl.uniprot.org/core/author | "Haigh T.A."xsd:string |