| http://purl.uniprot.org/citations/37481670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37481670 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration of macrophages during NASH by binding with its ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific ANGPTL8 knockout reduces MDM infiltration and resolves lipid accumulation and fibrosis progression in the livers of NASH mice. In addition, PirB-/- bone marrow (BM) chimeras abrogate ANGPTL8-induced MDM migration to the liver. And yet, PirB ectodomain protein could ameliorate NASH by sequestering ANGPTL8. Furthermore, LILRB2-ANGPTL8 binding-promoted MDM migration and inflammatory activation are also observed in human peripheral blood monocytes. Taken together, our findings reveal the role of PirB/LILRB2 in NASH pathogenesis and identify PirB/LILRB2-ANGPTL8 signaling as a potential target for the management or treatment of NASH."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-40183-3"xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "He R."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Wang S.Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Wang Z.H."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Yu X.F."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Li W.J."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Liu Z.L."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Ma D.L."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Meng X.Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Li D.P."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "He W.T."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Xie Y.Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Guo Y.M."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Xie J.H."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Shao S.Y."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Pan L.M."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Zou H.J."xsd:string |
| http://purl.uniprot.org/citations/37481670 | http://purl.uniprot.org/core/author | "Xu S.M."xsd:string |