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Objectives

To examine the relationship between endometrial integrin beta 5 level and risk of recurrent pregnancy loss.

Method

The descriptive, prospective, observational, case-controlstudy was conducted at the Kafrelsheikh University Hospital, Egypt, from January to May 2022, and comprised women aged up to 35 years with at least 1 live birth delivery beyond 20-week gestation with normal thyroid and prolactin levels. Age-matched normal fertile women were enrolled as controls. All the participants were subjected to detailed history and complete clinical examination. Endometrial integrin beta 5 was assessed using an antibody sandwich enzyme-linked immunosorbent assay. Data was analysed using SPSS 20.

Results

Of the 50 subjects, 25(50%) were cases with a mean age of 26.72±2.64 years, and 25(50%) were controls with a mean age of 25.36±2.16 years. The integrin beta 5 level was significantly lower among the cases than the controls (p<0.05). The best cut-off level of serum integrin beta 5 was ≤2.5765 with area under curve 0.886, sensitivity 88%, specificity 76%, positive predictive value 78.6%, negative predictive value 86.4%, and accuracy 82%.

Conclusions

Therewas an inverse correlationbetween endometrial integrinbeta 5 andthe risk ofrecurrentpregnancy loss."xsd:string
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http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/author"Abdelkarim A.M."xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/author"El Azeez Nosair N.A."xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/author"Ellakany M.F."xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/author"Fathy A.M."xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/author"Rizk A.Y."xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/name"J Pak Med Assoc 73(Suppl"xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/pages"S114-S117"xsd:string
http://purl.uniprot.org/citations/37482842http://purl.uniprot.org/core/title"Assessment Of Endometrial Integrin Beta 5 In Women With Unexplained Recurrent Pregnancy Loss."xsd:string
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