| http://purl.uniprot.org/citations/37487082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37487082 | http://www.w3.org/2000/01/rdf-schema#comment | "Recombination-promoting nuclease (Rpn) proteins are broadly distributed across bacterial phyla, yet their functions remain unclear. Here, we report that these proteins are toxin-antitoxin systems, comprised of genes-within-genes, that combat phage infection. We show the small, highly variable Rpn C-terminal domains (RpnS), which are translated separately from the full-length proteins (RpnL), directly block the activities of the toxic RpnL. The crystal structure of RpnAS revealed a dimerization interface encompassing α helix that can have four amino acid repeats whose number varies widely among strains of the same species. Consistent with strong selection for the variation, we document that plasmid-encoded RpnP2L protects Escherichia coli against certain phages. We propose that many more intragenic-encoded proteins that serve regulatory roles remain to be discovered in all organisms."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2307382120"xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Dyda F."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Hickman A.B."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Laub M.T."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Storz G."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Zhong A."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Klier K."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/author | "Teodoro G.I.C."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/pages | "e2307382120"xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/title | "Toxic antiphage defense proteins inhibited by intragenic antitoxin proteins."xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/37487082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37487082 |
| http://purl.uniprot.org/citations/37487082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37487082 |
| http://purl.uniprot.org/uniprot/#_P31667-mappedCitation-37487082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37487082 |
| http://purl.uniprot.org/uniprot/P31667 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37487082 |