| http://purl.uniprot.org/citations/37492931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37492931 | http://www.w3.org/2000/01/rdf-schema#comment | "Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting cells have some capacity to regenerate hair cells. However, their regenerative potential sharply declines as supporting cells undergo maturation (postnatal day 5 in mice). We recently reported that reactivation of the RNA-binding protein LIN28B restores the hair cell-regenerative potential of P5 cochlear supporting cells. Here, we identify the LIN28B target Trim71 as a novel and equally potent enhancer of supporting cell plasticity. TRIM71 is a critical regulator of stem cell behavior and cell reprogramming; however, its role in cell regeneration is poorly understood. Employing an organoid-based assay, we show that TRIM71 re-expression increases the mitotic and hair cell-forming potential of P5 cochlear supporting cells by facilitating their de-differentiation into progenitor-like cells. Our mechanistic work indicates that TRIM71's RNA-binding activity is essential for such ability, and our transcriptomic analysis identifies gene modules that are linked to TRIM71 and LIN28B-mediated supporting cell reprogramming. Furthermore, our study uncovers that the TRIM71-LIN28B target Hmga2 is essential for supporting cell self-renewal and hair cell formation."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.202256562"xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/author | "Morgan C."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/author | "Li X.J."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/author | "Kolanus W."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/author | "Doetzlhofer A."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/author | "Nadar-Ponniah P.T."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/pages | "e56562"xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/title | "TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells."xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/37492931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37492931 |
| http://purl.uniprot.org/citations/37492931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37492931 |
| http://purl.uniprot.org/uniprot/#_Q1PSW8-mappedCitation-37492931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37492931 |
| http://purl.uniprot.org/uniprot/Q1PSW8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37492931 |