| http://purl.uniprot.org/citations/37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37506699 | http://www.w3.org/2000/01/rdf-schema#comment | "During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to start leading-strand synthesis and every few hundred nucleotides during discontinuous lagging-strand replication. How Pol α-primase is targeted to replication forks to prime DNA synthesis is not fully understood. Here, by determining cryoelectron microscopy (cryo-EM) structures of budding yeast and human replisomes containing Pol α-primase, we reveal a conserved mechanism for the coordination of priming by the replisome. Pol α-primase binds directly to the leading edge of the CMG (CDC45-MCM-GINS) replicative helicase via a complex interaction network. The non-catalytic PRIM2/Pri2 subunit forms two interfaces with CMG that are critical for in vitro DNA replication and yeast cell growth. These interactions position the primase catalytic subunit PRIM1/Pri1 directly above the exit channel for lagging-strand template single-stranded DNA (ssDNA), revealing why priming occurs efficiently only on the lagging-strand template and elucidating a mechanism for Pol α-primase to overcome competition from RPA to initiate primer synthesis."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2023.06.035"xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/author | "Jones M.L."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/author | "Yeeles J.T.P."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/author | "Aria V."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/author | "Baris Y."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/pages | "2911-2924.e16"xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/title | "How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication."xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/37506699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37506699 |
| http://purl.uniprot.org/citations/37506699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37506699 |
| http://purl.uniprot.org/uniprot/#_P10363-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P53840-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_Q14181-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P09884-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P25205-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P29469-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P29496-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_P13382-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_Q03406-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_Q14691-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |
| http://purl.uniprot.org/uniprot/#_O75717-mappedCitation-37506699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37506699 |