http://purl.uniprot.org/citations/37530325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/37530325 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundColorectal carcinoma (CRC) is the most common malignancy of the gastrointestinal tract, representing an incredible health problem. It is essential to develop drugs against novel targets--involved in CRC tumorigenesis and progression--to improve the management of the disease. The aim of this study was to evaluate C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in CRC, and to associate their expression with the available clinicopathological parameters.Materials and methodsThis study included 50 cases of primary CRC. All cases were stained by CXCR4 and PPAR-γ antibodies to assess their immunohistochemical expression. The relations between their expression and clinicopathological variables were assessed.ResultsCXCR4 expression was detected in 76% of studied cases. High CXCR4 expression showed significant associations with the depth of tumor invasion (P = 0.024), lymph node metastasis (P = 0.009), advanced tumor stage (P = 0.001) and the presence of vascular invasion (P = 0.035). PPAR-γ expression was detected in 78% of studied cases. PPAR-γ expression showed a statistically significant inverse relation with histologic types (P = 0.001), tumor grade (P = 0.005), depth of tumor invasion (P = 0.001), lymph node status (P = 0.001), TNM stage (P = 0.002), and vascular invasion (P = 0.001).ConclusionsHigh CXCR4 and decreased PPAR-γ expressions are related to high tumor grade, advanced stage, and vascular invasion in colorectal carcinoma."xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.org/dc/terms/identifier | "doi:10.4103/ijpm.ijpm_481_21"xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/author | "Bedeer A.E."xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/author | "El-Ghaffar Heabah N.A."xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/name | "Indian J Pathol Microbiol"xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/pages | "465-471"xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/title | "Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression in colorectal carcinoma: Relation to the available clinicopathological parameters."xsd:string |
http://purl.uniprot.org/citations/37530325 | http://purl.uniprot.org/core/volume | "66"xsd:string |
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