| http://purl.uniprot.org/citations/37531208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37531208 | http://www.w3.org/2000/01/rdf-schema#comment | "Small molecules that regulate protein-protein interactions can be valuable drugs; however, the development of such small molecules is challenging as the molecule must interfere with an interaction that often involves a large surface area. Herein, we propose that modulating the conformational ensemble of the proteins participating in a given interaction, rather than blocking the interaction by directly binding to the interface, is a relevant strategy for interfering with a protein-protein interaction. In this study, we applied this concept to P-cadherin, a cell surface protein forming homodimers that are essential for cell-cell adhesion in various biological contexts. We first determined the crystal structure of P-cadherin with a small molecule inhibitor whose inhibitory mechanism was unknown. Molecular dynamics simulations suggest that the inhibition of cell adhesion by this small molecule results from modulation of the conformational ensemble of P-cadherin. Our study demonstrates the potential of small molecules altering the conformation ensemble of a protein as inhibitors of biological relevant protein-protein interactions."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.org/dc/terms/identifier | "doi:10.1002/pro.4744"xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Tsumoto K."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Kuroda D."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Caaveiro J.M.M."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Senoo A."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Ueno G."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/author | "Nagatoishi S."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/name | "Protein Sci"xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/pages | "e4744"xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/title | "Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/37531208 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37531208 |
| http://purl.uniprot.org/citations/37531208 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37531208 |
| http://purl.uniprot.org/uniprot/#_P22223-mappedCitation-37531208 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37531208 |
| http://purl.uniprot.org/uniprot/P22223 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37531208 |