| http://purl.uniprot.org/citations/37534176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37534176 | http://www.w3.org/2000/01/rdf-schema#comment | "The tardigrade-unique damage suppressor protein (Dsup) can protect DNA from ionizing radiation and reactive oxygen species (ROS). In this study, we generated Dsup-expressing lines of Drosophila melanogaster and demonstrated that Dsup increased the survival rate after γ-ray irradiation and hydrogen peroxide treatment in flies too, but reduced the level of their locomotor activity. The transcriptome analyses of Dsup-expressing lines revealed a significant number of DEGs, >99% of which were down-regulated. Moreover, Dsup could bind RNA. These findings suggest that Dsup can act not only as a DNA protector but also as a non-specific transcriptional repressor and RNA-binding protein, that may lead to disturbance of a number of biological processes in D. melanogaster. The obtained data demonstrate features of the Dsup protein action in non-tardigrade organisms and can be used to understand the impact of other unspecific DNA/RNA-binding proteins on ROS and radiation resistance, gene expression, and epigenetic processes."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2023.106998"xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Kravchenko E."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Alekseev S."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Zarubin M."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Mitrofanov S."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Azorskaya T."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/author | "Kuldoshina O."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/pages | "106998"xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/title | "The tardigrade Dsup protein enhances radioresistance in Drosophila melanogaster and acts as an unspecific repressor of transcription."xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/37534176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37534176 |
| http://purl.uniprot.org/citations/37534176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37534176 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFM4-mappedCitation-37534176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37534176 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K6N2-mappedCitation-37534176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37534176 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6B8-mappedCitation-37534176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37534176 |
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