| http://purl.uniprot.org/citations/37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37540802 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of coactivators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in CD8+ T-cell function. Here, we show that Ncoa2 promotes CD8+ T cell-mediated immune responses against tumors by stimulating T-cell activation via upregulating PGC-1α expression to enhance mitochondrial function. Mice deficient in Ncoa2 in T cells (Ncoa2fl/fl/CD4Cre) displayed defective immune responses against implanted MC38 tumors, which associated with significantly reduced tumor-infiltrating CD8+ T cells and decreased IFNγ production. Consistently, CD8+ T cells from Ncoa2fl/fl/CD4Cre mice failed to reject tumors after adoptive transfer into Rag1-/-mice. Further, in response to TCR stimulation, Ncoa2fl/fl/CD4Cre CD8+ T cells failed to increase mitochondrial mass, showed impaired oxidative phosphorylation, and had lower expression of PGC-1α, a master regulator of mitochondrial biogenesis and function. Mechanically, T-cell activation-induced phosphorylation of CREB triggered the recruitment of Ncoa2 to bind to enhancers, thus, stimulating PGC-1α expression. Forced expression of PGC-1α in Ncoa2fl/fl/CD4Cre CD8+ T cells restored mitochondrial function, T-cell activation, IFNγ production, and antitumor immunity. This work informs the development of Ncoa2-based therapies that modulate CD8+ T cell-mediated antitumor immune responses."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.org/dc/terms/identifier | "doi:10.1158/2326-6066.cir-23-0092"xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Wang Y.C."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Ouyang C."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Shang W."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Ann D.K."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/author | "Gwack Y."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/name | "Cancer Immunol Res"xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/pages | "1414-1431"xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/title | "Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1alpha Critical for Mitochondrial Function."xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/37540802 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37540802 |
| http://purl.uniprot.org/citations/37540802 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37540802 |
| http://purl.uniprot.org/uniprot/#_A6P3E3-mappedCitation-37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37540802 |
| http://purl.uniprot.org/uniprot/#_E9PV80-mappedCitation-37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37540802 |
| http://purl.uniprot.org/uniprot/#_Q3LIF9-mappedCitation-37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37540802 |
| http://purl.uniprot.org/uniprot/#_Q3LIG0-mappedCitation-37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37540802 |
| http://purl.uniprot.org/uniprot/#_Q3LIG2-mappedCitation-37540802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37540802 |