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http://purl.uniprot.org/citations/37552102http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Introduction

To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA).

Methods

In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included.

Results

HLA-B*53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence interval: 2.42-8.44, P = 1.46 × 10 -5 ). Phenytoin DILI showed the strongest association with HLA-B*53:01 (odds ratio: 9.17; 95% confidence interval: 3.61-23.28, P = 1.1 × 10 -5 ). The HLA-B*53:01 allele was carried by 8 of 9 AA phenytoin DILI cases.

Discussion

HLA-B*53:01 is a significant risk factor of liver injury due to antiepileptics, particularly phenytoin, in AA."xsd:string
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http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Li Y.J."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Phillips E."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Chalasani N."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Barnhart H."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Nicoletti P."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/author"Dellinger A."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/date"2024"xsd:gYear
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/name"Am J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/pages"200-202"xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/title"HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans."xsd:string
http://purl.uniprot.org/citations/37552102http://purl.uniprot.org/core/volume"119"xsd:string
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