| http://purl.uniprot.org/citations/37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37569581 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell cycle progression during development is meticulously coordinated with differentiation. This is particularly evident in the Drosophila 3rd instar eye imaginal disc, where the cell cycle is synchronized and arrests at the G1 phase in the non-proliferative region (NPR), setting the stage for photoreceptor cell differentiation. Here, we identify the transcription factor Nuclear Factor-YC (NF-YC) as a crucial player in this finely tuned progression, elucidating its specific role in the synchronized movement of the morphogenetic furrow. Depletion of NF-YC leads to extended expression of Cyclin A (CycA) and Cyclin B (CycB) from the FMW to the NPR. Notably, NF-YC knockdown resulted in decreased expression of Eyes absent (Eya) but did not affect Decapentaplegic (Dpp) and Hedgehog (Hh). Our findings highlight the role of NF-YC in restricting the expression of CycA and CycB in the NPR, thereby facilitating cell-cycle synchronization. Moreover, we identify the transcriptional cofactor Eya as a downstream target of NF-YC, revealing a new regulatory pathway in Drosophila eye development. This study expands our understanding of NF-YC's role from cell cycle control to encompass developmental processes."xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms241512203"xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/author | "Peng C.H."xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/author | "Lin M.D."xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/author | "Avellino A."xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/pages | "12203"xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/title | "Cell Cycle Regulation by NF-YC in Drosophila Eye Imaginal Disc: Implications for Synchronization in the Non-Proliferative Region."xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/37569581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37569581 |
| http://purl.uniprot.org/citations/37569581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37569581 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EG63-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |
| http://purl.uniprot.org/uniprot/#_M9NFR3-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |
| http://purl.uniprot.org/uniprot/#_P14785-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |
| http://purl.uniprot.org/uniprot/#_P07713-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |
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| http://purl.uniprot.org/uniprot/#_Q24031-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |
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| http://purl.uniprot.org/uniprot/#_M9ND38-mappedCitation-37569581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37569581 |