| http://purl.uniprot.org/citations/37580215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37580215 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) were recruited in Ghana. Mycobacterium (M.) tuberculosis sputum burden was monitored prior to and during treatment. Blood samples from all patients and controls were analyzed for IL-7Rα expression and T-cell markers by multi-colour flow cytometry. CD4+ and CD8+ T-cells of tuberculosis patients showed generally lower IL-7Rα expression as compared to controls. Concomitantly, tuberculosis patients had higher proportions of naïve and lower proportions of memory CD4+ T-cells. Notably, a subset of CD27 positive central memory T-cells (Tcm), which lacked IL-7Rα expression was enriched in tuberculosis patients as compared to controls. M. tuberculosis sputum burden was not associated with differences in IL-7Rα expression. Treatment duration and response showed no clear effects although IL-7Rα expression patterns were highly variable. These results suggested generally impaired generation of memory CD4+ T-cells and enrichment of a Tcm subset without IL-7Rα expression in patients with tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2023.08.141"xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Mayatepek E."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Jacobsen M."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Arthur J.F."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Seyfarth J."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Phillips R.O."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Adankwah E."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Owusu D.O."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Abass M.K."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Aniagyei W."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Batsa Debrah L."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Minadzi D."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Yeboah A."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Acheampong I."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Debrah A."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Gawusu A."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Kumbel F."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Laing E.F."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Lamptey M."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Osei-Yeboah F."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/author | "Vivekanandan M.M."xsd:string |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37580215 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |