| http://purl.uniprot.org/citations/37585286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37585286 | http://www.w3.org/2000/01/rdf-schema#comment | "Alcadein α (Alcα) and amyloid-β protein precursor (APP) are cargo receptors that associate vesicles with kinesin-1. These vesicles, which contain either Alcα or APP, transport various proteins/cargo molecules into axon nerve terminals. Here, we analyzed immune-isolated Alcα- and APP-containing vesicles of adult mouse brains with LC-MS/MS and identified proteins present in vesicles that contained either Alcα or APP. Among these proteins, Frizzled-5 (Fzd5), a Wnt receptor, was detected mainly in Alcα vesicles. Although colocalization ratios of Fzd5 with Alcα are low in the neurites of differentiating neurons by a low expression of Fzd5 in embryonic brains, the suppression of Alcα expression decreased the localization of Fzd5 in neurites of primary cultured neurons. Furthermore, Fzd5-EGFP expressed in primary cultured neurons was preferentially transported in axons with the transport velocities of Alcα vesicles. In synaptosomal fractions of adult-mice brains that express higher levels of Fzd5, the amount of Fzd5 and the phosphorylation level of calcium/calmodulin-dependent protein kinase-II were reduced in the Alcα-deficient mice. These results suggest that reduced transport of Fzd5 by Alcα-containing vesicles associated with kinesin-1 in axon terminals may impair the response to Wnt ligands in the noncanonical Ca2+-dependent signal transduction pathway at nerve terminals of mature neurons."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e22-10-0495"xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Taru H."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Kitamura A."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Hata S."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Kinjo M."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Takada R."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Shiraki Y."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Muller U.C."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Sobu Y."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/author | "Mitsuma M."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/pages | "ar110"xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/title | "Axonal transport of Frizzled5 by Alcadein alpha-containing vesicles is associated with kinesin-1."xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/37585286 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37585286 |
| http://purl.uniprot.org/citations/37585286 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37585286 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT1-mappedCitation-37585286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37585286 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQZ9-mappedCitation-37585286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37585286 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BR03-mappedCitation-37585286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37585286 |