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| http://purl.uniprot.org/citations/37590346 | http://www.w3.org/2000/01/rdf-schema#comment | "Protection of telomeres 1 (POT1) is the 3' single-stranded overhang-binding telomeric protein that prevents an ataxia telangiectasia and Rad3-related (ATR) DNA damage response (DDR) at chromosome ends. What precludes the DDR machinery from accessing the telomeric double-stranded-single-stranded junction is unknown. We demonstrate that human POT1 binds this junction by recognizing the phosphorylated 5' end of the chromosome. High-resolution crystallographic structures reveal that the junction is capped by POT1 through a "POT-hole" surface, the mutation of which compromises junction protection in vitro and telomeric 5'-end definition and DDR suppression in human cells. Whereas both mouse POT1 paralogs bind the single-stranded overhang, POT1a, not POT1b, contains a POT-hole and binds the junction, which explains POT1a's sufficiency for end protection. Our study shifts the paradigm for DDR suppression at telomeres by highlighting the importance of protecting the double-stranded-single-stranded junction."xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.adi2436"xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/author | "Nandakumar J."xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/author | "Tesmer V.M."xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/author | "Brenner K.A."xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/pages | "771-778"xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/title | "Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome."xsd:string |
| http://purl.uniprot.org/citations/37590346 | http://purl.uniprot.org/core/volume | "381"xsd:string |
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