| http://purl.uniprot.org/citations/37591465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37591465 | http://www.w3.org/2000/01/rdf-schema#comment | "The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed knockin mice expressing human TREM2-R47H from one mutant mouse Trem2 allele. TREM2-R47H mice showed increased seizure activity in response to an acute excitotoxin challenge, compared to wildtype controls or knockin mice expressing the common variant of human TREM2. TREM2-R47H also increased spontaneous thalamocortical epileptiform activity in App knockin mice expressing amyloid precursor proteins bearing autosomal dominant AD mutations and a humanized amyloid-β sequence. In mice with or without such App modifications, TREM2-R47H increased the density of putative synapses in cortical regions without amyloid plaques. TREM2-R47H did not affect synaptic density in hippocampal regions with or without plaques. We conclude that TREM2-R47H increases AD-related network hyperexcitability and that it may do so, at least in part, by causing an imbalance in synaptic densities across brain regions."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nbd.2023.106263"xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Gan L."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Petersen C."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Mao W."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Zahn A."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Smith N."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Das M."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Yu G.Q."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Mucke L."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Sayed F.A."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Paz J.T."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Lew I."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Necula D."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/author | "Voskobiynyk Y."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/pages | "106263"xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/title | "Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models."xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/37591465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37591465 |
| http://purl.uniprot.org/citations/37591465 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37591465 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT1-mappedCitation-37591465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37591465 |