| http://purl.uniprot.org/citations/37599828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37599828 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibro/adipogenic progenitors (FAPs) are skeletal muscle stromal cells that support regeneration of injured myofibers and their maintenance in healthy muscles. FAPs are related to mesenchymal stem cells (MSCs/MeSCs) found in other adult tissues, but there is poor understanding of the extent of similarity between these cells. Using single-cell RNA sequencing (scRNA-seq) datasets from multiple mouse tissues, we have performed comparative transcriptomic analysis. This identified remarkable transcriptional similarity between FAPs and MeSCs, confirmed the suitability of PDGFRα as a reporter for FAPs, and identified extracellular proteolysis as a new FAP function. Using PDGFRα as a cell surface marker, we isolated FAPs from healthy and dysferlinopathic mouse muscles and performed scRNA-seq analysis. This revealed decreased FAP-mediated Wnt signaling as a potential driver of FAP dysfunction in dysferlinopathic muscles. Analysis of FAPs in dysferlin- and dystrophin-deficient muscles identified a relationship between the nature of muscle pathology and alteration in FAP gene expression."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2023.107479"xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Jaiswal J.K."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Bonnemann C.G."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Hogarth M."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Uapinyoying P."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Panchapakesan K."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Mazala D.A.G."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/author | "Battacharya S."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/pages | "107479"xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/title | "Single-cell transcriptomic analysis of the identity and function of fibro/adipogenic progenitors in healthy and dystrophic muscle."xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/37599828 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37599828 |
| http://purl.uniprot.org/citations/37599828 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37599828 |
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