| http://purl.uniprot.org/citations/37615626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37615626 | http://www.w3.org/2000/01/rdf-schema#comment | "Macroautophagy/autophagy is a cellular recycling program regulating cell survival and controlling inflammatory responses in a context-dependent manner. Here, we demonstrate that keratinocyte-selective ablation of Atg16l1, an essential autophagy mediator, results in exacerbated inflammatory and neoplastic skin responses. In addition, mice lacking keratinocyte autophagy exhibit precocious onset of hair follicle growth, indicating altered activation kinetics of hair follicle stem cells (HFSCs). These HFSCs also exhibit expanded potencies in an autophagy-deficient context as shown by de novo hair follicle formation and improved healing of abrasion wounds. ATG16L1-deficient keratinocytes are markedly sensitized to apoptosis. Compound deletion of RIPK3-dependent necroptotic and CASP8-dependent apoptotic responses or of TNFRSF1A/TNFR1 reveals that the enhanced sensitivity of autophagy-deficient keratinocytes to TNF-dependent cell death is driving altered activation of HFSCs. Together, our data demonstrate that keratinocyte autophagy dampens skin inflammation and tumorigenesis but curtails HFSC activation by restraining apoptotic responses.Abbreviations: ATG16L1: autophagy related 16 like 1; DMBA: 2,4-dimethoxybenzaldehyde; DP: dermal papilla; EpdSCs: epidermal stem cells; Gas6: growth arrest specific 6; HF: hair follicle; HFSC: hair follicle stem cell; IFE: interfollicular epidermis; KRT5: keratin 5; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PMK: primary mouse keratinocyte; RIPK3: receptor-interacting serine-threonine kinase 3; scRNAseq: single-cell RNA-sequencing; SG: sebaceous gland; TEWL: transepidermal water loss; TPA: 12-O-tetradecanoylphorbol-13-acetate; TNF: tumor necrosis factor; TNFRSF1A/TNFR1: tumor necrosis factor receptor superfamily, member 1a; UMAP: uniform manifold approximation and projection."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2023.2247742"xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Toniolo A."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "van Loo G."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Hoste E."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Kasper M."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Van Hove L."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Maschalidi S."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Vandamme N."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Roels J."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Lecomte K."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Boone F."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Ciers M."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Ghiasloo M."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/author | "Raaijmakers K."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/pages | "2958-2971"xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/title | "Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation."xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/37615626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37615626 |
| http://purl.uniprot.org/citations/37615626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37615626 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-37615626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37615626 |