| http://purl.uniprot.org/citations/37627278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37627278 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal-fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms by which HLA-G regulates the immune function of NK cells. It highlights that HLA-G binds to microRNA to suppress NK cell cytotoxicity and stimulate the secretion of growth factors to support fetal growth. The interactions between HLA-G and NK cells also activate senescence signaling, promoting spiral artery remodeling and maintaining the balance of maternal-fetal immune responses. In addition, HLA-G can inhibit the function of decidual T cells, dendritic cells, and macrophages. Overall, the interaction between trophoblast cells and immune cells mediated by HLA-G plays a crucial role in understanding immune regulation at the maternal-fetal interface and offers insights into potential treatments for pregnancy-related diseases."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.org/dc/terms/identifier | "doi:10.3390/biom13081213"xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/author | "Ma F."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/name | "Biomolecules"xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/pages | "1213"xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/title | "The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy."xsd:string |
| http://purl.uniprot.org/citations/37627278 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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