| http://purl.uniprot.org/citations/37634319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37634319 | http://www.w3.org/2000/01/rdf-schema#comment | "The Human Leukocyte Antigen G (HLA-G) is an immunoregulatory molecule with a critical role in pregnancy success. HLA-G alleles are associated with differential susceptibility to multiple conditions, including gestational problems, infectious diseases, and viral persistence. Of note, both herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) can impair HLA-G expression, interfering with HLA-G-associated immunoregulation. On the other hand, the impacts of HLA-G alleles on susceptibility to Herpesviridae infection is a neglected issue. Therefore, this study evaluated HLA-G allele frequencies and their associations with placental Herpesviridae infection in women from southern Brazil. Placenta samples were collected soon after delivery, and detection of viral DNA of HSV-1, HSV-2 and human cytomegalovirus (HCMV) was performed by polymerase chain reaction (PCR). A fragment of HLA-G (exons 2-4) was amplified by PCR, sequenced, and analyzed to allele determination. One hundred and seventy women had their alleles determined. Overall, 25 HLA-G alleles were found, distributed into 56 different genotypes. The most frequent alleles were G* 01:01:01 and G* 01:01:02, found in 37.9 % and 16.5 % of samples, respectively. Among the 170 women, 89 (52.4 %) tested positive for Herpesviridae DNA in the placenta, 55 (32.3 %) tested negative, 3 (1.8 %) were negative for HSV-1 and HSV-2 (with absent HCMV data), and 23 (13.5 %) were undetermined. The G* 01:01:01 allele was significantly associated with an increased risk of placental HSV-1 infection (p = 0.0151; OR=1.837; IC=1.108-3.045). This study describes new information concerning placental HLA-G alleles in women from southern Brazil and helps explain how genetic background can modify susceptibility to placental infections."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jri.2023.104134"xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Soares M.A."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Soares E.A."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Alves B.M."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Chies J.A.B."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Finger-Jardim F."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Goncalves C.V."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "de Oliveira G.R."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Martinez A.M.B."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "da Hora V.P."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Avila E.C."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Ellwanger J.H."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Amaral S.C."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Lobato R.C."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Pivato A.F."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Sanchez-Luquez K."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/author | "Tornatore M."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/name | "J Reprod Immunol"xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/pages | "104134"xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/title | "HLA-G alleles and their impacts on placental HSV-1 infection in women from southern Brazil."xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/37634319 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37634319 |