| http://purl.uniprot.org/citations/37634811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37634811 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra and it is known to involve the accumulation of α-synuclein (α-syn), which is a neuroprotein that promotes degeneration of dopaminergic neurons. Serum/glucocorticoid-related kinase 1 (SGK1) is involved in the physiological and pathological processes in neurons. The aim of this study was to examine the relationship between SGK1 and α-syn expression in muscle tissue of a PD model and in C2C12 cells. Western blotting, immunohistochemistry, and immunofluorescence microscopy confirmed reduced SGK1 and increased α-syn expression in skeletal muscle of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice compared to the control group. To determine the relationship between SGK1 and α-syn, SGK1 small interfering RNA (siRNA) knockdown was performed in C2C12 cells, which showed that suppression of SGK1 levels resulted in increased α-syn expression. The main finding of our study is that reduction of SGK1 expression contributes to the pathogenesis of PD by increasing the expression of α-syn in skeletal muscle of MPTP-treated mice and C2C12 cells. This study confirms that decreased SGK1 induces increased α-syn expression in skeletal muscle, which suggests that maintaining SGK1 expression may improve PD symptoms."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2023.137464"xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/author | "Yeo S."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/author | "Heo E.J."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/author | "Hyung Seo M."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/pages | "137464"xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/title | "Association between SGK1 and alpha-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model."xsd:string |
| http://purl.uniprot.org/citations/37634811 | http://purl.uniprot.org/core/volume | "814"xsd:string |
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