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| http://purl.uniprot.org/citations/37637271 | http://www.w3.org/2000/01/rdf-schema#comment | "Schizosaccharomyces pombe Dim1 is a conserved essential component of the U4/U6.U5 tri-snRNP complex essential for pre-mRNA splicing. In a synthetic lethal screen with the temperature-sensitive dim1-35 mutant, we isolated multiple alleles of non-essential mtl16 that encodes the U6 snRNA m 6 A methyltransferase. Further genetic analysis revealed strong and specific negative genetic interactions between mtl16 and a mutation in the Dim1 binding partner, Prp31, and between dim1-35 and a mutation in the Prp31 binding partner, Prp6. Our work provides additional tools to study pre-mRNA splicing in S. pombe and biological confirmation of the importance of the Prp6-Prp31-Dim1-U6 snRNA interactions for pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.org/dc/terms/identifier | "doi:10.17912/micropub.biology.000948"xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/author | "Ren L."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/author | "Gould K.L."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/author | "Turner L.A."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/author | "Willet A.H."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/name | "MicroPubl Biol"xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/title | "Isolation of mutant alleles of the U6 snRNA m 6 A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/37637271 | http://purl.uniprot.org/core/volume | "2023"xsd:string |
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