| http://purl.uniprot.org/citations/37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37640805 | http://www.w3.org/2000/01/rdf-schema#comment | "The BCL-2 family protein BCL-RAMBO, also known as BCL2-like 13, anchors at the outer mitochondrial membrane and regulates apoptosis, mitochondrial fragmentation, and mitophagy. However, the mechanisms underlying the proapoptotic role of BCL-RAMBO remain unclear. In the present study, we demonstrated that BCL-RAMBO interacted with glucose-regulated protein 75 (GRP75), also known as heat shock protein family A member 9, and mortalin using co-immunoprecipitation and glutathione S-transferase-based pull-down assays. BCL-RAMBO interacted with GRP75 via its No BCL-2 homology domain. The interaction between BCL-RAMBO and GRP75 was confirmed by genetic interactions in Drosophila because a rough eye phenotype caused by the ectopic expression of BCL-RAMBO was partially suppressed by mutations in Hsc70-5, a mammalian GRP75 ortholog. In human embryonic kidney 293T cells, the co-expression of BCL-RAMBO and GRP75 facilitated an elevation in executioner caspase activity and poly (ADP-ribose) polymerase 1 (PARP-1) cleavage. In contrast, the knockdown of GRP75 suppressed elevated executioner caspase activity and PARP-1 cleavage in BCL-RAMBO-transfected cells. The mitochondrial release of cytochrome c induced by BCL-RAMBO was also attenuated by the knockdown of GRP75. These results indicate that GRP75 interacts with BCL-RAMBO and plays a crucial role in the BCL-RAMBO-dependent apoptosis signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-023-41196-0"xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Tanaka R."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Kawaguchi K."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Kataoka T."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/author | "Hashino T."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/pages | "14041"xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/title | "The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/37640805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37640805 |
| http://purl.uniprot.org/citations/37640805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37640805 |
| http://purl.uniprot.org/uniprot/#_A0A087WTL4-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MR90-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_A0A087WW80-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_A0A087WX97-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_E9PDD6-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_A1XP52-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_A0A384P5G6-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_B7Z1V7-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |
| http://purl.uniprot.org/uniprot/#_B7Z238-mappedCitation-37640805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37640805 |