| http://purl.uniprot.org/citations/37651925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37651925 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of the mammalian telencephalon, which is the most complex region of the central nervous system, is precisely orchestrated by many signaling molecules. Wnt signaling derived from the cortical hem, a signaling center, is crucial for telencephalic development including cortical patterning and the induction of hippocampal development. Secreted protein R-spondin (Rspo) 1-4 and their receptors, leucine-rich repeat-containing G-protein-coupled receptor (Lgr) 4-6, act as activators of Wnt signaling. Although Rspo expression in the hem during the early stages of cortical development has been reported, comparative expression analysis of Rspos and Lgr4-6 has not been performed. In this study, we examined the detailed spatiotemporal expression patterns of Rspo1-4 and Lgr4-6 in the embryonic and postnatal telencephalon to elucidate their functions. In the embryonic day (E) 10.5-14.5 telencephalon, Rspo1-3 were prominently expressed in the cortical hem. Among their receptors, Lgr4 was observed in the ventral telencephalon, and Lgr6 was highly expressed throughout the telencephalon at the same stages. This suggests that Rspo1-3 and Lgr4 initially regulate telencephalic development in restricted regions, whereas Lgr6 functions broadly. From the late embryonic stage, the expression areas of Rspo1-3 and Lgr4-6 dramatically expanded; their expression was found in the neocortex and limbic system, such as the hippocampus, amygdala, and striatum. Increased Rspo and Lgr expression from the late embryonic stages suggests broad roles of Rspo signaling in telencephalic development. Furthermore, the Lgr+ regions were located far from the Rspo+ regions, especially in the E10.5-14.5 ventral telencephalon, suggesting that Lgrs act via a Rspo-independent pathway."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gep.2023.119333"xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/author | "Horie M."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/author | "Mikami Y."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/author | "Hayatsu M."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/name | "Gene Expr Patterns"xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/pages | "119333"xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/title | "Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon."xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/37651925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37651925 |
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