| http://purl.uniprot.org/citations/37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37657612 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell-driven autoimmune responses are subject to striking sex-dependent effects. While the contributions of sex hormones are well-understood, those of sex chromosomes are meeting with increased appreciation. Here, we outline what is known about the contribution of sex chromosome-linked factors to experimental autoimmune encephalomyelitis (EAE), a mouse model that recapitulates many of the T cell-driven mechanisms of multiple sclerosis (MS) pathology. Particular attention is paid to the KDM family of histone demethylases, several of which - KDM5C, KDM5D and KDM6A - are sex chromosome encoded. Finally, we provide evidence that functional inhibition of KDM5 molecules can suppress interferon (IFN)γ production from murine male effector T cells, and that an increased ratio of inflammatory Kdm6a to immunomodulatory Kdm5c transcript is observed in T helper 17 (Th17) cells from women with the autoimmune disorder ankylosing spondylitis (AS). Histone lysine demethlyases thus represent intriguing targets for the treatment of T cell-driven autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainresbull.2023.110748"xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/author | "Ruda G.F."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/author | "Rangachari M."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/author | "Brennan P.E."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/author | "Fazazi M.R."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/name | "Brain Res Bull"xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/pages | "110748"xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/title | "The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/37657612 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37657612 |
| http://purl.uniprot.org/citations/37657612 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37657612 |
| http://purl.uniprot.org/uniprot/#_A0A087X0R0-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_A0A6M4C8G8-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_B4DG81-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_A0A804HJA2-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
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| http://purl.uniprot.org/uniprot/#_B4E253-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_B7ZKN1-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_B7ZKN5-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
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| http://purl.uniprot.org/uniprot/#_F4MHJ5-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |
| http://purl.uniprot.org/uniprot/#_F4MHK3-mappedCitation-37657612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37657612 |