| http://purl.uniprot.org/citations/37682220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37682220 | http://www.w3.org/2000/01/rdf-schema#comment | "Aerolysin-like pore-forming protein (af-PFP) superfamily members are double-edge swords that assist the bacterial infection but shied bacteria from the host by various mechanisms in some species including the toad Bombina maxima and zebrafish. While members of this family are widely expressed in all kingdoms, especially non-bacteria species, it remains unclear whether their anti-bacterial function is conserved. LIN-24 is an af-PFP that is constitutively expressed throughout the Caenorhabditis elegans lifespan. Here, we observed that LIN-24 knockdown reduced the maximum lifespan of worms. RNA-seq analysis identified 323 differentially expressed genes (DEGs) post-LIN-24 knockdown that were enriched in "immune response" and "lysosome pathway," suggesting a possible role for LIN-24 in resisting microbial infection. In line with this, we found that Pseudomonas aeruginosa 14 (PA14) infection induced LIN-24 expression, and that survival after PA14 infection was significantly reduced by LIN-24 knockdown. In contrast, LIN-24 overexpression (LIN-24-OE) conferred protection against PA14 infection, with worms showing longer survival time and reduced bacterial load. Weighted gene co-expression network analysis of LIN-24-OE worms showed that the highest correlation module was enriched in factors related to immunity and the defense response. Finally, by predicting transcription factors from RNA-seq data and knocking down candidate transcription factors in LIN-24-OE worms, we revealed that LIN-24 may protect worms against bacterial infection by stimulating DAF-16-mediated immune responses. These findings agree with our previous studies showing an anti-microbial role for the amphibian-derived af-PFP complex βγ-CAT, suggesting that af-PFPs may play a conserved role in combatting microbial infections. Further research is needed to determine the roles this protein family plays in other physio-pathological processes, such as metabolism, longevity, and aging."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.202300063r"xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Lee W."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Lan X."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/author | "Zhao M.M."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/pages | "e23162"xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection."xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/37682220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37682220 |
| http://purl.uniprot.org/citations/37682220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37682220 |
| http://purl.uniprot.org/uniprot/#_E5QCG5-mappedCitation-37682220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37682220 |
| http://purl.uniprot.org/uniprot/#_E5QCG6-mappedCitation-37682220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37682220 |
| http://purl.uniprot.org/uniprot/#_Q17410-mappedCitation-37682220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37682220 |