| http://purl.uniprot.org/citations/37683603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37683603 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoarthritis is a degenerative joint disease that causes pain, degradation, and dysfunction. Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic instability and loss of cartilage homeostasis; however, the regulatory niche is unknown. Using the temporomandibular joint as a model in multiple species, we identify Lgr5-expressing secretory cells as forming a Wnt inhibitory niche that instruct Wnt-inactive chondroprogenitors to form the nascent synovial joint and regulate chondrocyte lineage and identity. Lgr5 ablation or suppression during joint development, aging, or osteoarthritis results in depletion of Wnt-inactive chondroprogenitors and a surge of Wnt-activated, phenotypically unstable chondrocytes with osteoblast-like properties. We recapitulate the cartilage niche and create StemJEL, an injectable hydrogel therapy combining hyaluronic acid and sclerostin. Local delivery of StemJEL to post-traumatic osteoarthritic jaw and knee joints in rabbit, rat, and mini-pig models restores cartilage homeostasis, chondrocyte identity, and joint function. We provide proof of principal that StemJEL preserves the chondrocyte niche and alleviates osteoarthritis."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2023.08.004"xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Yao H."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Wei R."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Koch A."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Wilson M."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Wang T.C."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Forman M."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Embree M.C."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Tosa I."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Safina I."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Bonthius D."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Lecholop M.K."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Morel M.M."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Reeve G."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/author | "Ruscitto A."xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/37683603 | http://purl.uniprot.org/core/pages | "1179-1198.e7"xsd:string |