| http://purl.uniprot.org/citations/37686141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37686141 | http://www.w3.org/2000/01/rdf-schema#comment | "The human leukocyte antigen (HLA)-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disorder affecting the axial and peripheral joints, yet some HLA-B*27 variants not associated with AS have been shown. Since no major differences in the ligandome of associated compared to not-associated alleles have emerged, a plausible hypothesis is that the quantity rather than the quality of the presented epitopes makes the difference. In addition, the Endoplasmic Reticulum AminoPeptidases (ERAPs) 1 and 2, playing a crucial role in shaping the HLA class I epitopes, act as strong AS susceptibility factors, suggesting that an altered peptidome might be responsible for the activation of pathogenic CD8+ T cells. In this context, we have previously singled out a B*27:05-restricted CD8+ T cell response against pEBNA3A (RPPIFIRRL), an EBV peptide lacking the B*27 classic binding motif. Here, we show that a specific ERAP1/2 haplotype negatively correlates with such response in B*27:05 subjects. Moreover, we prove that the B*27:05 allele successfully presents peptides with the same suboptimal N-terminal RP motif, including the self-peptide, pDYNEIN (RPPIFGDFL). Overall, this study underscores the cooperation between the HLA-B*27 and ERAP1/2 allelic variants in defining CD8+ T cell reactivity to suboptimal viral and self-B*27 peptides and prompts further investigation of the B*27:05 peptidome composition."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms241713335"xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Molteni E."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Fiorillo M.T."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Sorrentino R."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Congia M."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "D'Abramo M."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Paladini F."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Alba J."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Tuosto L."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Di Franco M."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Cauli A."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Paroli M."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Scrivo R."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Tedeschi V."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Caccavale R."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/author | "Paldino G."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/pages | "13335"xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/title | "ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes."xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/37686141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37686141 |
| http://purl.uniprot.org/citations/37686141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37686141 |