| http://purl.uniprot.org/citations/37696945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37696945 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the high prevalence of heart failure in the western world, there are few effective treatments. Fibulin-3 is a protein involved in extracellular matrix (ECM) structural integrity, however its role in the heart is unknown. We have demonstrated, using single cell RNA-seq, that fibulin-3 was highly expressed in quiescent murine cardiac fibroblasts, with expression highest prior to injury and late post-infarct (from ~ day-28 to week-8). In humans, fibulin-3 was upregulated in left ventricular tissue and plasma of heart failure patients. Fibulin-3 knockout (Efemp1-/-) and wildtype mice were subjected to experimental myocardial infarction. Fibulin-3 deletion resulted in significantly higher rate of cardiac rupture days 3-6 post-infarct, indicating a weak and poorly formed scar, with severe ventricular remodelling in surviving mice at day-28 post-infarct. Fibulin-3 knockout mice demonstrated less collagen deposition at day-3 post-infarct, with abnormal collagen fibre-alignment. RNA-seq on day-3 infarct tissue revealed upregulation of ECM degradation and inflammatory genes, but downregulation of ECM assembly/structure/organisation genes in fibulin-3 knockout mice. GSEA pathway analysis showed enrichment of inflammatory pathways and a depletion of ECM organisation pathways. Fibulin-3 originates from cardiac fibroblasts, is upregulated in human heart failure, and is necessary for correct ECM organisation/structural integrity of fibrotic tissue to prevent cardiac rupture post-infarct."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-023-41894-9"xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Humphreys D.T."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Bailey T."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Graham R.M."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Harvey R.P."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Iismaa S.E."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Lee R.J."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Birner-Gruenberger R."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Hardy S.A."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Rainer P.P."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Ngo D.T."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Boyle A.J."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Patrick R."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Tomin T."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Bigland M.J."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Mabotuwana N.S."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Murtha L.A."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Chong J.J.H."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Hume R.D."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Raguram K."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/author | "Sverdlov A.L."xsd:string |
| http://purl.uniprot.org/citations/37696945 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |