| http://purl.uniprot.org/citations/37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37699442 | http://www.w3.org/2000/01/rdf-schema#comment | "Sensory difficulties represent a crucial issue in the life of autistic individuals. The diagnostic and statistical manual of mental disorders describes both hyper- and hypo-responsiveness to sensory stimulation as a criterion for the diagnosis autism spectrum disorders (ASD). Among the sensory domain affected in ASD, altered responses to tactile stimulation represent the most commonly reported sensory deficits. Although tactile abnormalities have been reported in monogenic cohorts of patients and genetic mouse models of ASD, the underlying mechanisms are still unknown. Traditionally, autism research has focused on the central nervous system as the target to infer the neurobiological bases of such tactile abnormalities. Nonetheless, the peripheral nervous system represents the initial site of processing of sensory information and a potential site of dysfunction in the sensory cascade. Here we investigated the gene expression deregulation in the trigeminal ganglion (which directly receives tactile information from whiskers) in two genetic models of syndromic autism (Shank3b and Cntnap2 mutant mice) at both adult and juvenile ages. We found several neuronal and non-neuronal markers involved in inhibitory, excitatory, neuroinflammatory and sensory neurotransmission to be differentially regulated within the trigeminal ganglia of both adult and juvenile Shank3b and Cntnap2 mutant mice. These results may help in disentangling the multifaced complexity of sensory abnormalities in autism and open avenues for the development of peripherally targeted treatments for tactile sensory deficits exhibited in ASD."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2023.08.028"xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/author | "Biasini E."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/author | "Bozzi Y."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/author | "Bonaldo V."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/author | "Balasco L."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/author | "Ciancone-Chama A.G."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/pages | "75-85"xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/title | "Gene Expression Profiling in Trigeminal Ganglia from Cntnap2-/- and Shank3b-/- Mouse Models of Autism Spectrum Disorder."xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://purl.uniprot.org/core/volume | "531"xsd:string |
| http://purl.uniprot.org/citations/37699442 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37699442 |
| http://purl.uniprot.org/citations/37699442 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE70-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG0-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG1-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG2-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG3-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG5-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A088DEG6-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A140LJB1-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A589M675-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH81-mappedCitation-37699442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37699442 |