| http://purl.uniprot.org/citations/37709749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37709749 | http://www.w3.org/2000/01/rdf-schema#comment | "HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling protein involved in DNA methylation. Its loss-of-function in humans causes humoral immunodeficiency, called ICF4 syndrome (Immunodeficiency, Centromeric Instability, Facial anomalies). Here we show by our newly generated B-cell-specific Hells conditional knockout mouse model that HELLS plays a pivotal role in T-dependent B-cell responses. HELLS deficiency induces accelerated decay of germinal center (GC) B cells and impairs the generation of high affinity memory B cells and circulating antibodies. Mutant GC B cells undergo dramatic DNA hypomethylation and massive de-repression of evolutionary recent retrotransposons, which surprisingly does not directly affect their survival. Instead, they prematurely upregulate either memory B cell markers or the transcription factor ATF4, which is driving an mTORC1-dependent metabolic program typical of plasma cells. Treatment of wild type mice with a DNMT1-specific inhibitor phenocopies the accelerated kinetics, thus pointing towards DNA-methylation maintenance by HELLS being a crucial mechanism to fine-tune the GC transcriptional program and enable long-lasting humoral immunity."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-41317-3"xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "De Smet A."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Reynaud C.A."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Storck S."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Weill J.C."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Boulard M."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Muegge K."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Lecoeuche D."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Cousu C."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Formichetti S."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/author | "Mulot E."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/pages | "5695"xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/title | "Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells."xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37709749 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37709749 |
| http://purl.uniprot.org/citations/37709749 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37709749 |
| http://purl.uniprot.org/uniprot/#_D3Z414-mappedCitation-37709749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37709749 |
| http://purl.uniprot.org/uniprot/#_Q60848-mappedCitation-37709749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37709749 |
| http://purl.uniprot.org/uniprot/D3Z414 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37709749 |
| http://purl.uniprot.org/uniprot/Q60848 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37709749 |