| http://purl.uniprot.org/citations/37713484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37713484 | http://www.w3.org/2000/01/rdf-schema#comment | "Translocations producing rearranged versions of the transcription factor double homeobox 4 (DUX4-r) are one of the most frequent causes of B cell acute lymphoblastic leukemia (B-ALL). DUX4-r retains the DNA binding domain of wild-type DUX4 but is truncated on the C-terminal transcription activation domain. The precise mechanism through which DUX4-r causes leukemia is unknown, and no targeted therapy is currently available. We found that the rearrangement leads to both a loss and a gain of function in DUX4-r. Loss of CBP/EP300 transcriptional coactivator interaction leads to an inability to bind and activate repressed chromatin. Concurrently, a gain of interaction with the general transcription factor 2 I (GTF2I) redirects DUX4-r toward leukemogenic targets. This neomorphic activity exposes an Achilles' heel whereby DUX4-r-positive leukemia cells are exquisitely sensitive to GTF2I targeting, which inhibits DUX4-r leukemogenic activity. Our work elucidates the molecular mechanism through which DUX4-r causes leukemia and suggests a possible therapeutic avenue tailored to this B-ALL subtype."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.adi3771"xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/author | "Gabellini D."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/author | "Salome M."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/author | "Biferali B."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/author | "Campolungo D."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/author | "Tascini A.S."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/pages | "eadi3771"xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/title | "DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/37713484 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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