| http://purl.uniprot.org/citations/37725138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37725138 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell regulator Pax5 consists of multiple domains whose function we analyzed in vivo by deletion in Pax5. While B lymphopoiesis was minimally affected in mice with homozygous deletion of the octapeptide or partial homeodomain, both sequences were required for optimal B cell development. Deletion of the C-terminal regulatory domain 1 (CRD1) interfered with B cell development, while elimination of CRD2 modestly affected B-lymphopoiesis. Deletion of CRD1 and CRD2 arrested B cell development at an uncommitted pro-B cell stage. Most Pax5-regulated genes required CRD1 or both CRD1 and CRD2 for their activation or repression as these domains induced or eliminated open chromatin at Pax5-activated or Pax5-repressed genes, respectively. Co-immunoprecipitation experiments demonstrated that the activating function of CRD1 is mediated through interaction with the chromatin-remodeling BAF, H3K4-methylating Set1A-COMPASS, and H4K16-acetylating NSL complexes, while its repressing function depends on recruitment of the Sin3-HDAC and MiDAC complexes. These data provide novel molecular insight into how different Pax5 domains regulate gene expression to promote B cell commitment and development."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20230260"xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/author | "Hill L."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/author | "Schafer M."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/author | "Jaritz M."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/author | "Gruenbacher S."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/pages | "e20230260"xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/title | "Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development."xsd:string |
| http://purl.uniprot.org/citations/37725138 | http://purl.uniprot.org/core/volume | "220"xsd:string |
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