| http://purl.uniprot.org/citations/37725888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37725888 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenosine kinase (ADK) plays the major role in cardiac adenosine metabolism, so that inhibition of ADK increases myocardial adenosine levels. While the cardioprotective actions of extracellular adenosine against ischemia/reperfusion (I/R) are well-established, the role of cellular adenosine in protection against I/R remains unknown. Here we investigated the role of cellular adenosine in epigenetic regulation on cardiomyocyte gene expression, glucose metabolism and tolerance to I/R. Evans blue/TTC staining and echocardiography were used to assess the extent of I/R injury in mice. Glucose metabolism was evaluated by positron emission tomography and computed tomography (PET/CT). Methylated DNA immunoprecipitation (MeDIP) and bisulfite sequencing PCR (BSP) were used to evaluate DNA methylation. Lentiviral/adenovirus transduction was used to overexpress DNMT1, and the OSI-906 was administered to inhibit IGF-1. Cardiomyocyte-specific ADK/IGF-1-knockout mice were used for mechanistic experiments.Cardiomyocyte-specific ADK knockout enhanced glucose metabolism and ameliorated myocardial I/R injury in vivo. Mechanistically, ADK deletion caused cellular adenosine accumulation, decreased DNA methyltransferase 1 (DNMT1) expression and caused hypomethylation of multiple metabolic genes, including insulin growth factor 1 (IGF-1). DNMT1 overexpression abrogated these beneficial effects by enhancing apoptosis and decreasing IGF-1 expression. Inhibition of IGF-1 signaling with OSI-906 or genetic knocking down of IGF-1 also abrogated the cardioprotective effects of ADK knockout, revealing the therapeutic potential of increasing IGF-1 expression in attenuating myocardial I/R injury. In conclusion, the present study demonstrated that cardiomyocyte ADK deletion ameliorates myocardial I/R injury via epigenetic upregulation of IGF-1 expression via the cardiomyocyte adenosine/DNMT1/IGF-1 axis."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.redox.2023.102884"xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Gao R."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Zou Y."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Huo Y."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Fan F."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Sun A."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Qian S."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/author | "Fassett J."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/name | "Redox Biol"xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/pages | "102884"xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/title | "Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model."xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/37725888 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37725888 |
| http://purl.uniprot.org/citations/37725888 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37725888 |