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http://purl.uniprot.org/citations/37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/37741911http://www.w3.org/2000/01/rdf-schema#comment"

Aims

High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes.

Methods

Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population.

Results

Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd.

Conclusion

G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.org/dc/terms/identifier"doi:10.1007/s00592-023-02118-8"xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Schlessinger D."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Fiorillo E."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Lakatta E.G."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Scuteri A."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Cucca F."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Marongiu M."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Orru M."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"Morrell C.H."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/author"AlGhatrif M."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/date"2024"xsd:gYear
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/name"Acta Diabetol"xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/pages"127-130"xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/title"Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes."xsd:string
http://purl.uniprot.org/citations/37741911http://purl.uniprot.org/core/volume"61"xsd:string
http://purl.uniprot.org/citations/37741911http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/37741911
http://purl.uniprot.org/citations/37741911http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/37741911
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http://purl.uniprot.org/uniprot/#_Q0PHS2-mappedCitation-37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37741911
http://purl.uniprot.org/uniprot/#_Q0PHS3-mappedCitation-37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37741911
http://purl.uniprot.org/uniprot/#_Q0PHS4-mappedCitation-37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37741911
http://purl.uniprot.org/uniprot/#_Q0PHS5-mappedCitation-37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37741911
http://purl.uniprot.org/uniprot/#_Q0PHS6-mappedCitation-37741911http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37741911
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