| http://purl.uniprot.org/citations/37798283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37798283 | http://www.w3.org/2000/01/rdf-schema#comment | "Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active TG3 requires proteolytic cleavage between the core domain and two C-terminal β-barrels (C1C2). Here, we report four X-ray crystal structures representing inactive and active conformations of human TG3 in complex with a TG3-specific Fab fragment of a DH patient derived antibody. We demonstrate that cleaved TG3, upon binding of a substrate-mimicking inhibitor, undergoes a large conformational change as a β-sheet in the catalytic core domain moves and C1C2 detaches. The unique enzyme-substrate conformation of TG3 without C1C2 is recognized by DH autoantibodies. The findings support a model where B-cell receptors of TG3-specific B cells bind and internalize TG3-gluten enzyme-substrate complexes thereby facilitating gluten-antigen presentation, T-cell help and autoantibody production."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-42004-z"xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/author | "Sollid L.M."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/author | "Heggelund J.E."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/author | "Stamnaes J."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/author | "Iversen R."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/pages | "6216"xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/title | "Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3."xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37798283 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37798283 |
| http://purl.uniprot.org/citations/37798283 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37798283 |
| http://purl.uniprot.org/uniprot/#_Q08188-mappedCitation-37798283 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37798283 |
| http://purl.uniprot.org/uniprot/Q08188 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37798283 |