| http://purl.uniprot.org/citations/37802055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37802055 | http://www.w3.org/2000/01/rdf-schema#comment | "Identifying the cells from which cancers arise is critical for understanding the molecular underpinnings of tumor evolution. To determine whether stem/progenitor cells can serve as cells of origin, we created a Msi2-CreERT2 knock-in mouse. When crossed to CAG-LSL-MycT58A mice, Msi2-CreERT2 mice developed multiple pancreatic cancer subtypes: ductal, acinar, adenosquamous, and rare anaplastic tumors. Combining single-cell genomics with computational analysis of developmental states and lineage trajectories, we demonstrate that MYC preferentially triggers transformation of the most immature MSI2+ pancreas cells into multi-lineage pre-cancer cells. These pre-cancer cells subsequently diverge to establish pancreatic cancer subtypes by activating distinct transcriptional programs and large-scale genomic changes, and enforced expression of specific signals like Ras can redirect subtype specification. This study shows that multiple pancreatic cancer subtypes can arise from a common pool of MSI2+ cells and provides a powerful model to understand and control the programs that shape divergent fates in pancreatic cancer."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2023.09.008"xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Diaz E."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Tsai S."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Han H."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Goggins M.G."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Wen K.W."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Hamilton M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Wechsler-Reya R.J."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Fox R."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Quintero C.M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Reya T."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "McDermott M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Kritzik M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Newman A.M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Lowy A.M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Von Hoff D.D."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Rajbhandari N."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Lytle N.K."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Schurch C.M."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Ferguson L.P."xsd:string |
| http://purl.uniprot.org/citations/37802055 | http://purl.uniprot.org/core/author | "Cridebring D."xsd:string |