| http://purl.uniprot.org/citations/37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37803019 | http://www.w3.org/2000/01/rdf-schema#comment | "While disorders in lipid metabolism have been associated with aging and age-related diseases, how lipid metabolism is regulated during aging is poorly understood. Here, we characterize the Drosophila endoribonuclease CG2145, an ortholog of mammalian EndoU that we named Age-related lipid regulator (Arlr), as a regulator of lipid homeostasis during aging. In adult adipose tissues, Arlr is necessary for maintenance of lipid storage in lipid droplets (LDs) as flies age, a phenotype that can be rescued by either high-fat or high-glucose diet. Interestingly, RNA-seq of arlr mutant adipose tissues and RIP-seq suggest that Arlr affects lipid metabolism through the degradation of the mRNAs of lipolysis genes - a model further supported by the observation that knockdown of Lsd-1, regucalcin, yip2 or CG5162, which encode genes involved in lipolysis, rescue the LD defects of arlr mutants. In addition, we characterize DendoU as a functional paralog of Arlr and show that human ENDOU can rescue arlr mutants. Altogether, our study reveals a role of ENDOU-like endonucleases as negative regulator of lipolysis."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-42042-7"xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/author | "Kong X."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/pages | "6254"xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/title | "The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging."xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37803019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37803019 |
| http://purl.uniprot.org/citations/37803019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37803019 |
| http://purl.uniprot.org/uniprot/P21128#attribution-D91F32765077F688476CFCA58325B868 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHZ1-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q76NR6-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q9VCI3-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q8SXG0-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q9NIU5-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q9VF14-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q9VZ49-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_X2JJD6-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |
| http://purl.uniprot.org/uniprot/#_Q9VL70-mappedCitation-37803019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37803019 |