| http://purl.uniprot.org/citations/37804592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37804592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37804592 | http://www.w3.org/2000/01/rdf-schema#comment | "Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels composed of five homologous subunits. The homopentameric α7-nAChR, abundantly expressed in the brain, is involved in the regulation of the neuronal plasticity and memory and undergoes phosphorylation by protein kinase A (PKA). Here, we extracted native α7-nAChR from murine brain, validated its assembly by cryo-EM and showed that phosphorylation by PKA in vitro enables its interaction with the abundant human brain protein 14-3-3ζ. Bioinformatic analysis narrowed the putative 14-3-3-binding site down to the fragment of the intracellular loop (ICL) containing Ser365 (Q361RRCSLASVEMS372), known to be phosphorylated in vivo. We reconstructed the 14-3-3ζ/ICL peptide complex and determined its structure by X-ray crystallography, which confirmed the Ser365 phosphorylation-dependent canonical recognition of the ICL by 14-3-3. A common mechanism of nAChRs' regulation by ICL phosphorylation and 14-3-3 binding that potentially affects nAChR activity, stoichiometry, and surface expression is suggested."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2023.09.086"xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2023.09.086"xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kirpichnikov M.P."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kirpichnikov M.P."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kulbatskii D.S."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kulbatskii D.S."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Lyukmanova E.N."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Lyukmanova E.N."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Popov V.O."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Popov V.O."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Shulepko M.A."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Shulepko M.A."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Boyko K.M."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Boyko K.M."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Sluchanko N.N."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Sluchanko N.N."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Varfolomeeva L.A."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Varfolomeeva L.A."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Minyaev M.E."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Minyaev M.E."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kapitonova A.A."xsd:string |
| http://purl.uniprot.org/citations/37804592 | http://purl.uniprot.org/core/author | "Kapitonova A.A."xsd:string |