| http://purl.uniprot.org/citations/3785200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3785200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3785200 | http://www.w3.org/2000/01/rdf-schema#comment | "Five mouse alpha-tubulin isotypes are described, each distinguished by the presence of unique amino acid substitutions within the coding region. Most, though not all of these isotype-specific amino acids, are clustered at the carboxy terminus. One of the alpha-tubulin isotypes described is expressed exclusively in testis and is encoded by two closely related genes (M alpha 3 and M alpha 7) which have homologous 3' untranslated regions but which differ at multiple third codon positions and in their 5' untranslated regions. We show that a subfamily of alpha-tubulin genes encoding the same testis-specific isotype also exists in humans. Thus, we conclude that the duplication event leading to a pair of genes encoding a testis-specific alpha-tubulin isotype predated the mammalian radiation, and both members of the duplicated sequence have been maintained since species divergence. A second alpha-tubulin gene, M alpha 6, is expressed ubiquitously at a low level, whereas a third gene, M alpha 4, is unique in that it does not encode a carboxy-terminal tyrosine residue. This gene yields two transcripts: a 1.8-kilobase (kb) mRNA that is abundant in muscle and a 2.4-kb mRNA that is abundant in testis. Whereas the 1.8-kb mRNA encodes a distinct alpha-tubulin isotype, the 2.4-kb mRNA is defective in that the methionine residue required for translational initiation is missing. Patterns of developmental expression of the various alpha-tubulin isotypes are presented. Our data support the view that individual tubulin isotypes are capable of conferring functional specificity on different kinds of microtubules."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.6.7.2409-2419.1986"xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.6.7.2409-2419.1986"xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Cowan N.J."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Cowan N.J."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Lewis S.A."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Lewis S.A."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Villasante A."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Villasante A."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Dobner P."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Dobner P."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Dolph P."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/author | "Dolph P."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/pages | "2409-2419"xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/pages | "2409-2419"xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/title | "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes."xsd:string |
| http://purl.uniprot.org/citations/3785200 | http://purl.uniprot.org/core/title | "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes."xsd:string |