| http://purl.uniprot.org/citations/37870842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37870842 | http://www.w3.org/2000/01/rdf-schema#comment | "Smooth muscle tumors are the most common mesenchymal tumors of the female genital tract, including the vulva. Since vulvar smooth muscle tumors are rare, our understanding of them compared to their uterine counterparts continues to evolve. Herein, we present two cases of morphologically distinct myxoid epithelioid smooth muscle tumors of the vulva with novel MEF2D::NCOA2 gene fusion. The tumors involved 24 and 37-year-old women. Both tumors presented as palpable vulvar masses that were circumscribed, measuring 2.8 and 5.1 cm in greatest dimension. Histologically, they were composed of epithelioid to spindle-shaped cells with minimal cytologic atypia and prominent myxoid matrix. Rare mitotic figures were present (1-3 mitotic figures per 10 high-power field (HPF)), and no areas of tumor necrosis were identified. By immunohistochemistry, the neoplastic cells strongly expressed smooth muscle actin, calponin, and desmin, confirming smooth muscle origin. Next-generation sequencing identified identical MEF2D::NCOA2 gene fusions. These two cases demonstrate that at least a subset of myxoid epithelioid smooth muscle tumors of the vulva represent a distinct entity characterized by a novel MEF2D::NCOA2 gene fusion. Importantly, recognition of the distinct morphologic and genetic features of these tumors is key to understanding the biological potential of these rare tumors."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.org/dc/terms/identifier | "doi:10.1002/gcc.23209"xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Mustafa A."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Davis J.L."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Zou Y.S."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Ulbright T.M."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Warmke L.M."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/author | "Segura S.E."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/name | "Genes Chromosomes Cancer"xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/pages | "e23209"xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/title | "Myxoid epithelioid smooth muscle tumor of the vulva: A distinct entity with MEF2D::NCOA2 gene fusion."xsd:string |
| http://purl.uniprot.org/citations/37870842 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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