| http://purl.uniprot.org/citations/37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37872182 | http://www.w3.org/2000/01/rdf-schema#comment | "Dimerization of C-type lectin receptors (CLRs) or Toll-like receptors (TLRs) can alter their ligand binding ability, thereby modulating immune responses. However, the possibilities and roles of dimerization between CLRs and TLRs remain unclear. Here we show that C-type lectin receptor-2d (CLEC2D) forms homodimers, as well as heterodimers with TLR2. Quantitative ligand binding assays reveal that both CLEC2D homodimers and CLEC2D/TLR2 heterodimers have a higher binding ability to fungi-derived β-glucans than TLR2 homodimers. Moreover, homo- or hetero-dimeric CLEC2D mediates β-glucan-induced ubiquitination and degradation of MyD88 to inhibit the activation of transcription factor IRF5 and subsequent IL-12 production. Clec2d-deficient female mice are resistant to infection with Candida albicans, a human fungal pathogen, owing to the increase of IL-12 production and subsequent generation of IFN-γ-producing NK cells. Together, these data indicate that CLEC2D forms homodimers or heterodimers with TLR2, which negatively regulate antifungal immunity through suppression of IRF5-mediated IL-12 production. These homo- and hetero-dimers of CLEC2D and TLR2 provide an example of receptor dimerization to regulate host innate immunity against microbial infections."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-42216-3"xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/author | "Jia X.M."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/author | "Li Y.Q."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/pages | "6718"xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/title | "C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity."xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37872182 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37872182 |
| http://purl.uniprot.org/citations/37872182 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37872182 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_F5BFH0-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_Q811T5-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_P08905-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_Q8K3D9-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_Q91V08-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/#_Q9QUN7-mappedCitation-37872182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/Q9QUN7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37872182 |
| http://purl.uniprot.org/uniprot/P08905 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37872182 |