| http://purl.uniprot.org/citations/37908721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37908721 | http://www.w3.org/2000/01/rdf-schema#comment | "Rationale: Increased methylation of key genes has been observed in kidney diseases, suggesting that the ten-eleven translocation (Tet) methyl-cytosine dioxygenase family as well as 5mC oxidation may play important roles. As a member of the Tet family, the role of Tet1 in acute kidney injury (AKI) remains unclear. Methods: Tet1 knockout mice, with or without tempol treatment, a scavenger of reactive oxygen species (ROS), were challenged with ischemia and reperfusion (I/R) injury or unilateral ureteral obstruction (UUO) injury. RNA-sequencing, Western blotting, qRT-PCR, bisulfite sequencing, chromatin immunoprecipitation, immunohistochemical staining, and dot blot assays were performed. Results: Tet1 expression was rapidly upregulated following I/R or UUO injury. Moreover, Tet1 knockout mice showed increased renal injury and renal cell death, increased ROS accumulation, G2/M cell cycle arrest, inflammation, and fibrosis. Severe renal damage in injured Tet1 knockout mice was alleviated by tempol treatment. Mechanistically, Tet1 reduced the 5mC levels in an enzymatic activity-dependent manner on the promoters of Sod1 and Sod2 to promote their expression, thus lowering injury-induced excessive ROS and reducing I/R or UUO injury. Conclusions: Tet1 plays an important role in the development of AKI by promoting SOD expression through a DNA demethylase-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.org/dc/terms/identifier | "doi:10.7150/thno.87416"xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Huang K."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Jin M."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Xiong M."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Petersen R.B."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/author | "Peng A."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/name | "Theranostics"xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/pages | "5348-5364"xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/title | "Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase."xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/37908721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37908721 |
| http://purl.uniprot.org/citations/37908721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37908721 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MAW8-mappedCitation-37908721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37908721 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHT7-mappedCitation-37908721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37908721 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MHU2-mappedCitation-37908721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37908721 |
| http://purl.uniprot.org/uniprot/#_A0A0B7MGW8-mappedCitation-37908721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37908721 |