| http://purl.uniprot.org/citations/37932427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37932427 | http://www.w3.org/2000/01/rdf-schema#comment | "The placenta and tumors can exhibit a shared expression profile of proto-oncogenes. The basis of placenta-derived heat shock protein gp96, which induces prophylactic and therapeutic T cell responses against cancer including hepatocellular carcinoma (HCC), remains unknown. Here, we identified the associated long peptides from human placental gp96 using matrix-assisted laser desorption/ionization-time-of-flight and mass spectrometry and analyzed the achieved proteins through disease enrichment analysis. We found that placental gp96 binds to numerous peptides derived from 73 proteins that could be enriched in multiple cancer types. Epitope-harboring peptides from glypican 3 (GPC3) and paternally expressed gene 10 (PEG10) were the major antigens mediating anti-HCC T cell immunity. Molecular docking analysis showed that the GPC3- and PEG10-derived peptides, mainly obtained from the cytotrophoblast layer of the mature placenta, bind to the lumenal channel and client-bound domain of the gp96 dimer. Immunization with bone marrow-derived dendritic cells pulsed with recombinant gp96-GPC3 or recombinant gp96-PEG10 peptide complex induced specific T cell responses, and T cell transfusion led to pronounced growth inhibition of HCC tumors in nude mice. We demonstrated that the chaperone gp96 can capture antigenic peptides as an efficient approach for defining tumor rejection oncoantigens in the placenta and provide a basis for developing GPC3 and PEG10 peptide-based vaccines against HCC. This study provides insight into the underlying mechanism of the antitumor response mediated by embryonic antigens from fetal tissues, and this will incite more studies to identify potential tumor rejection antigens from placenta."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-023-03569-2"xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Cheng F."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Meng S."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Tian H."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Ju Y."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/pages | "4337-4354"xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/title | "GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/37932427 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37932427 |
| http://purl.uniprot.org/citations/37932427 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37932427 |
| http://purl.uniprot.org/uniprot/#_A0A087WZG9-mappedCitation-37932427 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37932427 |