| http://purl.uniprot.org/citations/37934943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37934943 | http://www.w3.org/2000/01/rdf-schema#comment | "Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease [NAFLD]) and metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis [NASH]) are leading chronic liver diseases, driving cirrhosis, hepatocellular carcinoma, and mortality. MASLD/MASH is associated with increased senescence proteins, including Activin A, and senolytics have been proposed as a therapeutic approach. To test the role of Activin A, we induced hepatic expression of Activin A in a murine MASLD/MASH model. Surprisingly, overexpression of hepatic Activin A dramatically mitigated MASLD, reducing liver steatosis and inflammation as well as systemic fat accumulation, while improving insulin sensitivity. Further studies identified a dramatic decrease in the lipid-associated macrophages marker glycoprotein NMB (Gpnmb) by Activin A, and Gpnmb knockdown in the same model produced similar benefits and transcriptional changes to Activin A expression. These studies reveal a surprising protective role for Activin A in MASLD and the potential for SASP proteins to have context-specific beneficial effects. Moreover, they implicate both Activin A and Gpnmb as potential therapeutic targets for this condition.Article highlights"xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.org/dc/terms/identifier | "doi:10.2337/db23-0357"xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Cai B."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Hastings M.H."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Soukas A.A."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Svensson K.J."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Rosenzweig A."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Westerhoff M."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Yerevanian A."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/author | "Guerra J.R.B."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/date | "2024"xsd:gYear |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/pages | "260-279"xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/title | "Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)."xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/37934943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37934943 |
| http://purl.uniprot.org/citations/37934943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37934943 |
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| http://purl.uniprot.org/uniprot/#_Q3TWC7-mappedCitation-37934943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37934943 |
| http://purl.uniprot.org/uniprot/#_Q3TAV1-mappedCitation-37934943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37934943 |
| http://purl.uniprot.org/uniprot/#_Q3TBB0-mappedCitation-37934943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37934943 |