| http://purl.uniprot.org/citations/37958735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37958735 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse erythropoiesis is a multifaceted process involving the intricate interplay of proliferation, differentiation, and maturation of erythroid cells, leading to significant changes in their transcriptomic and proteomic profiles. While the immunoregulatory role of murine erythroid cells has been recognized historically, modern investigative techniques have been sparingly applied to decipher their functions. To address this gap, our study sought to comprehensively characterize mouse erythroid cells through contemporary transcriptomic and proteomic approaches. By evaluating CD71 and Ter-119 as sorting markers for murine erythroid cells and employing bulk NanoString transcriptomics, we discerned distinctive gene expression profiles between bone marrow and fetal liver-derived erythroid cells. Additionally, leveraging flow cytometry, we assessed the surface expression of CD44, CD45, CD71, and Ter-119 on normal and phenylhydrazine-induced hemolytic anemia mouse bone marrow and splenic erythroid cells. Key findings emerged: firstly, the utilization of CD71 for cell sorting yielded comparatively impure erythroid cell populations compared to Ter-119; secondly, discernible differences in immunoregulatory molecule expression were evident between erythroid cells from mouse bone marrow and fetal liver; thirdly, two discrete branches of mouse erythropoiesis were identified based on CD45 expression: CD45-negative and CD45-positive, which had been altered differently in response to phenylhydrazine. Our deductions underscore (1) Ter-119's superiority over CD71 as a murine erythroid cell sorting marker, (2) the potential of erythroid cells in murine antimicrobial immunity, and (3) the importance of investigating CD45-positive and CD45-negative murine erythroid cells separately and in further detail in future studies."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms242115752"xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Sennikov S."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Shevchenko J."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Alrhmoun S."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Nazarov K."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Perik-Zavodskaia O."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Perik-Zavodskii R."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/author | "Volynets M."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/pages | "15752"xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/title | "Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells."xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/37958735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37958735 |
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| http://purl.uniprot.org/uniprot/#_S4R1M0-mappedCitation-37958735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37958735 |