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Importance

Inactivation of EP300/CREBB paralogous cellular lysine acetyltransferases (KATs) during the early phase of infection is a consistent feature of DNA viruses. The cell responds by stabilizing transcription factor IRF3 which activates transcription of scores of interferon-stimulated genes (ISGs), inhibiting viral replication. Human respiratory adenoviruses counter this by assembling a CUL4-based ubiquitin ligase complex that polyubiquitinylates RUVBL1 and 2 inducing their proteasomal degradation. This inhibits accumulation of active IRF3 and the expression of anti-viral ISGs, allowing replication of the respiratory HAdVs in the face of inhibition of EP300/CBEBBP KAT activity by the N-terminal region of E1A."xsd:string
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http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Sha J."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Wohlschlegel J.A."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Berk A.J."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Hsu E."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Barshop W.D."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/author"Zemke N.R."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/name"J Virol"xsd:string
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http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/title"Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress."xsd:string
http://purl.uniprot.org/citations/37962355http://purl.uniprot.org/core/volume"97"xsd:string
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