| http://purl.uniprot.org/citations/37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37970674 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation by the small modifier SUMO is heavily dependent on spatial control of enzymes that mediate the attachment and removal of SUMO on substrate proteins. Here, we show that in the fission yeast Schizosaccharomyces pombe, delocalisation of the SUMO protease Ulp1 from the nuclear envelope results in centromeric defects that can be attributed to hyper-SUMOylation at the nuclear periphery. Unexpectedly, we find that although this localised hyper-SUMOylation impairs centromeric silencing, it can also enhance centromere clustering. Moreover, both effects are at least partially dependent on SUMOylation of the inner nuclear membrane protein Lem2. Lem2 has previously been implicated in diverse biological processes, including the promotion of both centromere clustering and silencing, but how these distinct activities are coordinated was unclear; our observations suggest a model whereby SUMOylation serves as a regulatory switch, modulating Lem2 interactions with competing partner proteins to balance its roles in alternative pathways. Our findings also reveal a previously unappreciated role for SUMOylation in promoting centromere clustering."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.260868"xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Zhao N."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Leidecker O."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Bayne E.H."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Chapman E."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Spanos C."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Spoel S.H."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Le Coz C."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Strachan J."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/author | "Arsenijevic A."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/pages | "jcs260868"xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/title | "SUMOylation regulates Lem2 function in centromere clustering and silencing."xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/37970674 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37970674 |
| http://purl.uniprot.org/citations/37970674 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37970674 |
| http://purl.uniprot.org/uniprot/#_P0C016-mappedCitation-37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37970674 |
| http://purl.uniprot.org/uniprot/#_P15398-mappedCitation-37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37970674 |
| http://purl.uniprot.org/uniprot/#_P52808-mappedCitation-37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37970674 |
| http://purl.uniprot.org/uniprot/#_P54069-mappedCitation-37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37970674 |
| http://purl.uniprot.org/uniprot/#_Q1K9C2-mappedCitation-37970674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37970674 |