| http://purl.uniprot.org/citations/37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37990886 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim: Conservative treatment approaches for thyroid carcinoma (TC) patients with wild-type B-type Raf kinase (BRAF) pose risks of long-term recurrence. The association of DNA methylation with TC metastasis is unclear. Patients & methods: Here we analyzed data from 179 BRAF wild-type TC patients in the The Cancer Genome Atlas database, identifying significant metastasis-associated CpGs. A logistic regression model was developed and validated for discriminating lymphatic metastasis in BRAF wild-type TC. Results: The model showed high accuracy (AUC: 0.924 training set; 0.812 and 0.773 external cohorts). TAGLN, MRPL4, CLDN10 and GRIK2 emerged as diagnostic markers. GRIK2, downregulated due to promoter hypermethylation, acted as a TC suppressor. Conclusion: Our 5-CpG epigenetic signature effectively discriminates lymphatic metastasis in BRAF wild-type TC, highlighting GRIK2's tumor-suppressive role influenced by promoter hypermethylation."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.org/dc/terms/identifier | "doi:10.2217/epi-2023-0334"xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Lin F."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Yang A."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/author | "Ke C."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/name | "Epigenomics"xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/pages | "1101-1119"xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/title | "Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2."xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/37990886 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37990886 |
| http://purl.uniprot.org/citations/37990886 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37990886 |
| http://purl.uniprot.org/uniprot/#_A0A8D9PH75-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_A0A804HHV9-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_A8K7F0-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_A8K0H7-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_D7RWZ8-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_B7Z8P6-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_G3XAD3-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |
| http://purl.uniprot.org/uniprot/#_Q13002-mappedCitation-37990886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37990886 |